Mystery cases keep the doctors busy at the clinic. Tutti, a one-year-old cockatiel won't stop throwing up. Toothless, a six-month-old veiled chameleon, has a swollen eye and his owner believes one of his food crickets bit him. And Snowball, a three-year-old pine snake, has stopped laying her eggs, and Dr. K. will do whatever it takes to save her.

An arctic fox named Dinah comes in acting lethargic and won't eat or drink. Dr. T is concerned she may have gotten into something toxic, but she'll need to do an exam and run tests to know for sure. And while Lola, a fourteen-year-old cockatiel is in for a routine checkup, Dr. K discovers her sinuses are very inflamed. Dr. K must work carefully as a tiny bird doesn't have much blood to spare.

It's never a dull moment at the clinic with Biggie, a rescued potbellied pig that needs an eyelift, Fred, a quail attacked by a flock-mate that tries to escape, Buddy, a bearded dragon who is all choked up on his lunch and an adorable skunk named Ophelia, who lets loose on the staff. And Dr. K works to save Mifi, a four-month-old baby rabbit with a large mass in his stomach.