Stakes are high at Dr. K's Exotic Animal ER as the team rushes to save Lil Bit, a prairie dog with a swollen face and life-threatening infection, and Croquetta, a potbellied pig close to choking on a large piece of fruit. They also must perform an emergency surgery on an obstructed bunny named Po and get to the bottom of Serena's serious duck trouble.

It's a day of mystery at Dr. K's clinic when Crystal, a bearded dragon suffers a mysterious illness, Willie Nelson, a sweet prairie dog has an unexpected reaction to surgery and Leo a sulcata tortoise is run over by a car. Meanwhile, Cleo, a swan with a drooping wing worries Dr. T.

A small ferret named Maximus has a big problem, and the team works to help the little creature with a large lump on his face. And Dr. K works to help Daisy, a baby bunny with an injured foot takes an unexpected turn. It's a busy day in the clinic as the team also works to help a feather-plucking cockatoo with an attitude, and a yellow-bellied slider turtle that needs emergency surgery.