Xenon, an 8-month-old fennec fox, is not able to put any weight on her swollen front leg and Dr. T suspects Xenon has a broken wrist. Monkey, a two-and-a-half-year-old bush baby, is new to his family and has been self-mutilating his tail and needs Dr. K's help, and Marshmallow, a one-year old dwarf hamster, is the smallest patient of the day, having trouble breathing.

Peanut, a one-year-old ferret, has bloody urine and Dr. K suspects a urinary tract infection but tests reveal a totally different and surprising problem, while Buddy, a baby skunk, comes in with a bloated belly and Ponchito, a sun conure, gets a string caught around his leg and risks losing his foot. Nugget, a three-year-old rabbit, has a concerning cheek abscess.

Stakes are high at Dr. K's Exotic Animal ER as the team rushes to save Lil Bit, a prairie dog with a swollen face and life-threatening infection, and Croquetta, a potbellied pig close to choking on a large piece of fruit. They also must perform an emergency surgery on an obstructed bunny named Po and get to the bottom of Serena's serious duck trouble.