After concealing poison in capsules, Captain Karan Sachdev reaches Skyline flight 502. Soon after take-off, Karan starts panicking when his co-pilot is accidentally poisoned. He cuts off communication with ground control which raises further suspicion and ATC officer Kiran Mirza is called in.

After both the co-pilots are poisoned, Karan calls ATC and requests for an emergency landing. Anticipating a case of hijacking, Kiran calls in the Anti-Terrorist Squad for help.

Passenger Krishnamurthy is joined by his student Siddharth and their conversation about life and death opens a Pandora's box. Meanwhile, ATS officer Kale provokes Karan who then refuses to land the plane.