George H.W. Bush becomes a loyal vice president to Ronald Regan but his wife Barbara falls out with jealous First Lady Nancy. George W. commits to a life of sobriety while becoming the father of twin daughters. With a newfound purpose, he helps propel his father to become the 41st President of the United States.

The Bushes have finally made it to the White House but having a father as a president hits Neil Bush hard when scandals strike. George H.W. triumphs against Saddam but the Bush family suffer a bitter election defeat and the loss of their matriarch Dorothy.

George W. and Jeb Bush are two brothers determined to make it to the Governor's mansion but only one will succeed. Laura Bush fears the consequences of having a second president in the family but she can't stop her husband becoming "43" who soon faces his greatest ever test as America comes under attack.