Blinded by loyalty to his president and ignoring the advice of his family, George H.W. Bush is betrayed by Richard Nixon. His children start to follow in his footsteps, a young Jeb gets married to Columba while George W. falls in love with Laura. The Bushes rally behind George H.W. as he makes a bid for the White House.

George H.W. Bush becomes a loyal vice president to Ronald Regan but his wife Barbara falls out with jealous First Lady Nancy. George W. commits to a life of sobriety while becoming the father of twin daughters. With a newfound purpose, he helps propel his father to become the 41st President of the United States.

The Bushes have finally made it to the White House but having a father as a president hits Neil Bush hard when scandals strike. George H.W. triumphs against Saddam but the Bush family suffer a bitter election defeat and the loss of their matriarch Dorothy.