When two people share the same flashbacks/regressive episodes, Kate, Price, Malachi and Rishi discover the couple are star-crossed lovers who rediscover each other in each life, and the team must go to great lengths to keep the pair from fulfilling a destructive pattern.

When a young girl exhibits physical manifestations from traumatic past-life memories, she is dubbed a saint by the media and is brought to the team's attention. From saint to sinner, the "Saint" Sarah case leads Kate and Price to a serial killer.

When an office worker with no previous psychiatric history is accused of stealing, he erupts in a violent outburst forcing his co-workers to call in the Talmadge team. Kate and Price travel with their patient to Texas only to discover he was involved in a violent crime.