Gizmo the Lhatese has a knee surgically repaired by Dr. Brendon Ringwood; Shih-poo Niko seeks help from Dr. James for hind legs that are on the decline; Dr. Regan Williams finds an arrhythmia while examining Chloe the boxer's heart.

Young Saint Bernard Harley sees Dr. Debbie James when her legs begin to fail; kitten Loki is found to have a heart murmur during a routine vaccination, and Dr. Regan Williams suspects a congenital heart defect but does an ultrasound to learn more.

At the local zoo, Pinky the cheetah needs Dr. Sharon French's help to fix a broken tooth; Dr. Jon Forbes treats poodle Mocha after an unfortunate encounter with a larger dog; golden retriever Shadow seeks help from Dr. Regan Williams for heartworm.