Bruce Lee the cat donates some blood and Dr. Bryer oversees the procedure, Charlie the golden retriever is carrying an unusually large tumor that Dr. Boyd wants to remove and Dr. Williams faces difficult circumstances when treating Star's ailing heart.

Dr. French helps Pinky the cheetah with her broken tooth, an aging golden retriever named Brody has a physical therapy session to soothe his pain and Dr. James tries to help disoriented Max the Shih Tzu find out which way is up.

When Chihuahua Reilly breaks a leg, Dr. Boyd performs surgery, a cat named Jerry survives a house fire, but his gums suffer due to smoke inhalation and Dr. Williams consults with Dr. Cochrane to treat Cyril the cat's high blood pressure.