When a young St. Bernard's legs begin to fail, Dr. James enlists the help of Dr. Kilburn, Dr. Williams deals with a large pup plagued by a heartworm infestation and Dr. Bryer investigates a mysterious breathing issue affecting a newly adopted cat.

After discovering a tooth abscess in elderly feline Ginny, Dr. French enlists the help of other VEC specialists to help her endure surgery and Dr. Bryer partners with the head vet technician to save Pomeranian puppy Ella from a deadly virus.

Bruce Lee the cat donates some blood and Dr. Bryer oversees the procedure, Charlie the golden retriever is carrying an unusually large tumor that Dr. Boyd wants to remove and Dr. Williams faces difficult circumstances when treating Star's ailing heart.