Dr. French relieves Rowdy the lion of an infected tooth after Dr. Williams gets him safely sedated, Dr. James helps a cat whose spine needs saving and a Jack Russell terrier turns out to have bigger problems than Dr. James thought.

When a young St. Bernard's legs begin to fail, Dr. James enlists the help of Dr. Kilburn, Dr. Williams deals with a large pup plagued by a heartworm infestation and Dr. Bryer investigates a mysterious breathing issue affecting a newly adopted cat.

After discovering a tooth abscess in elderly feline Ginny, Dr. French enlists the help of other VEC specialists to help her endure surgery and Dr. Bryer partners with the head vet technician to save Pomeranian puppy Ella from a deadly virus.