Mazy the Bichon Frise has had a few seizures, and her owners seek neurological care from Dr. James, who suspects a brain tumor or inflammatory disease, Dr. Boyd spays Komodo dragon Loka and Dr. Martin helps Titan the cat with respiratory issues.

Dr. Williams uses ultrasound to test Shadow the golden retriever for heartworms and Dr. Boyd attempts to treat Tiger the cat's severely burned paws after a tragic house fire.

Dr. Williams finds that elderly cat Chloe may have hypertrophic cardiomyopathy and Dr. James suspects that internal bleeding from a knitting needle injury may be causing Alien the cat's motor function issue.