Life coach Iyanla Vanzant travels to Los Angeles to work with Bonnie, a woman in crisis, whose weight has spiraled to a staggering 600 pounds, confining her to her home and bed for years. In this gripping episode, Iyanla helps Bonnie examine the emotional road that led to her health crisis, beginning with the death of her mother and the increasingly deteriorating relationship with her daughter and caretaker, Jamesha. Through one-on-one therapy sessions with Bonnie and revealing joint sessions with Jamesha, Iyanla works to repair their relationship and lead Bonnie to a healthier lifestyle and a loving future with her daughter.

Life coach Iyanla Vanzant travels to St. Louis to tackle a dysfunctional relationship among business co-owners and sisters Laurie and Anna and their sister/employee, Crystal. Consistent miscommunication and gossiping threaten to destroy their successful healthcare business and to rip their entire family apart. In a highly emotional episode, Iyanla uncovers how Laurie's daughter, Raquel, may be at the center of the sisters' destructive relationships.

Iyanla visits a Chicago mother supporting seven people under her roof, including her two adult children, their partners and two grandchildren. As the only member of the household with a steady job, Alma has been watching her home descend into chaos and has been struggling to keep afloat. Can Iyanla help this family find a way out of their close quarters?