The Crown Prince is enthroned with the backing of Queen Dowager. But Lee Geum is surprised to hear that his closest allies decided to resign and leave the palace. The deal was sealed so that the Patriarchs could support the king. Meanwhile, Wi Byeong Joo escapes from his place of exile and an epidemic begins to spread.

A mysterious plague spreads across the whole nation within days. As if the epidemic wasn't enough, news that Prince Mil Poong and Wi Byung Ju have escaped from their place of exile shocks the whole palace. Dal Moon just begins to collect information that many wells around the nation has been tasting strange lately.

Due to one hideous note that was scattered around the streets of Hanyang, people's distrust in His Majesty intensifies. Patients at the Hwalinseo refuse to be treated and more are demanding to open up the gates to escape the city. Finally, His Majesty decides to meet the people himself and tell them that he will be by their side, no matter what.