Yonkers first responders Alex and Jamal face unexpected challenges when they respond to a call for a man with a broken ankle who fell from a fire escape. The night really starts to heat up for Steven Lopez and Sam Netheron in Tucson when they are called to a structure fire and must search inside for possible victims. Things get personal for Niki Johnson in Baton Rouge when a call for a patient with back pain takes an emotional turn.

In Austin, Luddy and Finch practice parking lot medicine when they respond to a heroin overdose on a 19-year-old patient. Niki and Nicole show their compassionate side to a young woman suffering from an emotional trauma in Baton Rouge. After the final call of the night, Yonkers medic Alex reveals a sobering truth about her past.

In Austin, Texas, a man is shot by someone he trusts and Kim and Audrey must wait until the gunman is apprehended before they can begin treatment. Meanwhile in Yonkers, New York, Cunningham and Ariel face an emotional call that hits too close to home. The Baton Rouge, Louisiana, community is hit hardest tonight when Niki and Nicole are faced with the task of trying to save a life of a fellow service member.