In Baton Rouge, Lacey and Stacey restrain a patient suffering from violent hallucinations after overdosing on the synthetic drug Mojo. Meanwhile, Matt and Henry face the most difficult challenge paramedics encounter when an Austin man calls 911 to save his wife from cardiac arrest. And in Yonkers, New York, Alex and Jamal must determine what drug caused a woman to go unresponsive before her heart stops beating.

Yonkers first responders Alex and Jamal face unexpected challenges when they respond to a call for a man with a broken ankle who fell from a fire escape. The night really starts to heat up for Steven Lopez and Sam Netheron in Tucson when they are called to a structure fire and must search inside for possible victims. Things get personal for Niki Johnson in Baton Rouge when a call for a patient with back pain takes an emotional turn.

In Austin, Luddy and Finch practice parking lot medicine when they respond to a heroin overdose on a 19-year-old patient. Niki and Nicole show their compassionate side to a young woman suffering from an emotional trauma in Baton Rouge. After the final call of the night, Yonkers medic Alex reveals a sobering truth about her past.