Casey's birthmark covers most of her face, head and neck. James has mysterious growths on his inner thigh and lower abdomen that are completely puzzling. Jerry had to hang up his rock star vocal cords when a lump grew out the side of his throat.

Elizabeth's head is covered with giant cauliflower-shaped bumps. Jamaal has been growing a strange knob on the left side of his butt since he was just a boy. Donna's cracking, bleeding skin condition has aged her face and kept her from being social.

Elaine calls the growth on her love handle her third breast; Jessica's cyst is close to her eye and could be dangerous for Dr. Lee to remove; Dwayne wants his nose bumps removed, but he may not be able to make it through the pain of the procedure.