Johnnie's crippling psoriasis keeps him from spending time with his daughter. Aimee has a mohawk of cysts on her head. Edith's face markings and itchy skin condition turn out to be more than she expected.

Dr. Lee faces off with iguana-wrangler Madison's head growths; Chanel suffers from painful cyst tunnels beneath her armpit skin that leak and smell like the food she eats; the dark purple birthmark on Eddie's nose has made him a recluse.

Robert has thousands of unique bumps on his arms that Dr. Lee has never seen. Alexis has a painful cheek cyst that oozes and has a pungent odour. Stuart's cluster of back bumps disgusts his wife, but thrills Dr. Lee.