Jeremy is a pastor with a hanging growth in an embarrassing location. Evelyn has recurring keloids that have been removed three times and come back bigger each time. Todd has a bump protruding from his forehead that is painful and humiliating.

Tameru is a drag queen, but he has a myriad of cysts that are the real drag. Devon has uneven skin she thinks may be the result of a hysterectomy a decade ago. Amy has large growths all over her head that make her look like a "hot mess."

Jason has lost confidence and motivation due to the large growth on his neck. Shawnell has multiple mystery bumps on her head that have destroyed her self-esteem. Jim has a growth protruding off of his nose, making it hard to breathe.