Dr. Sandra Lee treats Heather, who has a huge growth on her leg and fears removing it could leave a keloid scar; Paul has a giant hump on his back.

Tim has a massive growth on his back that affects his ability to work and socialize. Daniel has debilitating psoriasis that covers 90% of his body. Gloriana and Yolanda are a mother/daughter duo who have bonded over their bumps.

Traci's confidence has been destroyed after years of bullying from the bumps on her face; Ravon has a unique dangling growth on his leg; David has a large lump.