Rhonda has bumps all over her head, including a horned growth that has her deeply concerned; Fred has a mysterious condition on his hands and has not been able to get answers from any doctors; Kevin has a huge lump protruding from his hip.

Dr. Sandra Lee treats Heather, who has a huge growth on her leg and fears removing it could leave a keloid scar; Paul has a giant hump on his back.

Tim has a massive growth on his back that affects his ability to work and socialize. Daniel has debilitating psoriasis that covers 90% of his body. Gloriana and Yolanda are a mother/daughter duo who have bonded over their bumps.