Killer bees are spreading across the southern U.S. These angry and aggressive bees attack by the thousands, sometimes stinging their victims to death. When a man is trapped inside his home with killer bees, the Venom One team needs to get him to safety.

Florida is faced with a new invasion - African Nile monitor lizards. These carnivorous lizards are moving into new areas and brazenly entering people's yards and patios. They will eat almost anything in their path, even people.

A monstrous Burmese python is lurking near a daycare, and these pythons from the swamp are capable of devouring a meal the size of a twelve-year-old. And extracting venom from the deadly King Cobra could save lives, but it could also quickly claim them.