As a giant hurricane rapidly approaches the coast of South Florida, the Venom One team races to lockdown a 400 pound gator, angry crocodiles and venomous snakes. If they're not secured properly, the hurricane could release them into the streets of Miami.

Killer bees are spreading across the southern U.S. These angry and aggressive bees attack by the thousands, sometimes stinging their victims to death. When a man is trapped inside his home with killer bees, the Venom One team needs to get him to safety.

Florida is faced with a new invasion - African Nile monitor lizards. These carnivorous lizards are moving into new areas and brazenly entering people's yards and patios. They will eat almost anything in their path, even people.