An alligator blocking a roadway tries to rip off Lt. Lisa Wood's leg. A deadly rattlesnake strikes out from underneath thick brush, and when the Venom One team gets called out to a dog rescue, they find not one, but three killer snakes.

Chuck & Ernie have captured every deadly reptile in the Everglades, so now they venture to Costa Rica for the ultimate snakation, all in search of the largest pit viper ever, the Black Headed Bushmaster.