Be careful sticking your hand in the mailbox, because the deadliest snake in North America could be waiting to bite. Plus Capt. Seifert must capture a 12-foot python with amazing speed and agility, and when Capt. Fobb closes in on another python.

Pythons are pushing out into people's yards, killing and consuming any animals in their path. When a python is captured with a meal in its stomach, the Venom One team must find out if someone's pet is inside.

As a giant hurricane rapidly approaches the coast of South Florida, the Venom One team races to lockdown a 400 pound gator, angry crocodiles and venomous snakes. If they're not secured properly, the hurricane could release them into the streets of Miami.