The ER is quarantined, which prevents Kayo from going to her sister's wedding, detains Doyle's accountant and jeopardizes a sick runaway.

A department-store explosion creates a major disaster as patients are rushed to Manhattan General during the midst of the Christmas season.

Cliff puts a patient's life at risk when, concentrating more on his social life than on work, he fails to prescribe an essential medication, and Kayo takes the blame.