Four patients with serious illness arrive at the NIH's Building 10 to enter potentially groundbreaking clinical trials and rest their hopes on the brilliant minds that work there.

While Bo Cooper recovers from a near-death experience, Anita McAlister weighs her treatment options. Patients Lucy Wiese and Deidra Williams receive highly experimental bone marrow transplants.

Bo Cooper starts another round of experimental therapy for his end-stage leukaemia. Lucy Weise gets the results of her transplant and sickle cell patient Deidra gets good news.