Wayne Wolfe Jr. discovers his grandfather was the serial killer Edward Wayne Edwards and teams up with retired detective John Cameron. They examine Edwards as a suspect in various murder cases including The Zodiac, JonBenet Ramsey and many more.

Wayne and John head to San Francisco where they examine Edwards involvement in one of the most chilling unsolved cases in American history – the Zodiac murders. Wayne visits his relatives to find out more about his grandfather.

John Cameron has a theory that Edwards was capable of killing children, including the child beauty queen JonBenet Ramsey and the Atlanta Child killer. Wayne learns about the murder of Ed's foster son, Dannie Boy Edwards.