The Rubbles are forced to move in with Fred and Wilma while a plumber fixes Fred's "repair job," which did far more harm than the Rubbles' original problem. What began as a simple leak ends up becoming a very major, week-long plumbing job. During the Rubbles' stay, Barney causes so many problems for Fred that he finally loses his patience and blows his top with Barney. Meanwhile, Wilma is angry at Betty and begins to fight with her. After Fred and Barney overhear Wilma and Betty fighting, they stop fighting, make up, and get the wives to also make up, leaving everything correct again between both the Flintstones and the Rubbles.

Dino's x-rays are mistaken for Fred's. As a result, Wilma, Betty, and Barney think Fred has the illness Dino has ("dinopeptitis"). This causes them to keep Fred awake for 24 hours straight and take a trip to the roller skating rink, where Fred falls asleep on his skates despite having twenty or thirty cups of coffee.

During the Flintstones's honeymoon, Fred gambled, but Wilma believes he's been cured of his habit. Then Arnold the newsboy tempts him to bet on a single marbles game. Can Wilma save Fred before he starts betting and losing all the furniture in the house?