The original plan called for renovating the home, but the "Extreme Makeover: Home Edition" team found that the house was beyond renovation. It was on the verge of being red-tagged because of, among other things, lack of heat, a leaky bathtub, broken windows and an old carpet so full of dust that it would give the kids frequent allergies. When the EMHE team realized this, it was decided to completely tear down the house and rebuild it from scratch! The nearly-impossible feat of building a new house from the foundation up in just seven days is revealed.

When a young girl was diagnosed with sun poisoning, it completely changed her life and that of her family. She is unable to go outside without first completely covering her body with a long-sleeved shirt, long pants, hat and gloves. Since the sun can also penetrate her clothing, she must apply full body sunscreen every two hours. With the combined effort from the team of designers, contractors, hundreds of workers and state-of-the-art technology, "Extreme Makeover: Home Edition" created a new living space that will enhance the quality of her life while making her living conditions much less restrictive.

After their infant daughter received a heart transplant to save her from the same condition that their son died of as a newborn, Cathy and Bill Grinnan made a promise that they would do whatever they could to educate others about heart disease. Despite their personal tragedies, the Grinnan family became crusaders for heart disease research and treatment. Now it's time for someone to give back to them.