Dr. Lavigne performs a doggy nose job to help a pug with bad breathing problems. Dr. Blue urgently treats Hardtime, a dog who's facing hard times battling heart disease. An opossum with a traumatic injury needs Dr. Ross's help.

The docs head to the Renaissance Faire to tend to the birds of prey in need of the West Nile vaccine. Piper the peppy dachshund is not herself and Dr. Lavigne must perform surgery. Meanwhile, Dr. Ross treats Tesla the tortoise for a fractured beak.

Dr. Lavigne does a not so routine surgery on a hermaphrodite dog that's both male and female. A bearded dragon is battling a skin disease that Dr. Ross must treat before it causes serious problems. Dr. Blue manages work and a big family move.