We follow three vets and their families as they begin new lives and careers in Houston. It's a big move to a big state, but they dream big, and they're determined to make this work -- for their families, and for the animals of Houston.

A chicken is rushed to Dr. Ross after being attacked by a coyote. When a Great Dane mix has a seizure, Dr. Lavigne uncovers multiple issues. A surprise serenade at the clinic musically inspires Dr. Blue.

Dr. Lavigne performs a doggy nose job to help a pug with bad breathing problems. Dr. Blue urgently treats Hardtime, a dog who's facing hard times battling heart disease. An opossum with a traumatic injury needs Dr. Ross's help.