The doctors prepare to open a new clinic but are apprehensive about a promise they made to each other regarding the event. Dr. Ross tends to a frizzle hen's eye problem while Dr. Blue is alarmed by a bulldog's burst mammary gland.

We follow three vets and their families as they begin new lives and careers in Houston. It's a big move to a big state, but they dream big, and they're determined to make this work -- for their families, and for the animals of Houston.

A chicken is rushed to Dr. Ross after being attacked by a coyote. When a Great Dane mix has a seizure, Dr. Lavigne uncovers multiple issues. A surprise serenade at the clinic musically inspires Dr. Blue.