Dr. Blue performs a difficult surgery on a Dalmatian being weighed down by a grapefruit-sized tumor on his head; Dr. Ross brings his family together to get a service dog for his brother Tedric, who has been suffering from seizures his whole life.

Dr. Ross closely examines a duck with a lump in his throat. Dr. Lavigne uses x-ray film during surgery in a very unexpected way, while Dr. Blue tries to uncover a guinea pig mystery at the clinic. Dr. Lavigne's wife joins a local roller derby team.

Dr. Lavigne is tasked with removing a six-pound mass from a small dog. Dr. Blue and wife welcome their first daughter. The vets make a house call to a llama that's causing some drama. Dr. Ross extracts a whopping 14 teeth from a mini poodle.