Dr. Lavigne performs a risky surgery on a loving pit bull with a record-breaking tumor; Dr. Ross examines a rescue pigeon turned pet; an aspiring vet student joins Dr. Blue at Cy-Fair; the doctors deal with a heartbreaking situation at the clinic.

Bubby Cook the Basset Hound has a condition that could complicate surgery for Dr. Ross. Dr. Blue has a hog house call, and Dr. Lavigne has concerns over his vet tech assisting with an operation on her own dog. A blackout creates chaos at Cy-Fair.

Yuki the bulldog ate something she shouldn't have and it's up to Dr. Blue to find it; Dr. Lavigne and his wife learn how to do alternative home care on Suki, an amputee rescue cat his family adopted.