Dr. Blue flies into action when a rottweiler in labor gets rushed into the hospital with two puppies stuck inside her; the three vets grab the reins and their cowboy hats to ride horseback into town for Houston's biggest rodeo parade.

The doctors visit their alma mater for a class reunion and become professors for a day; a shih tzu is rushed to the clinic after swallowing a large piece of rawhide, while the owner of a pit bull with a deformed leg must consider drastic surgery.

The doctors are honored for their contributions to the community; a goat with a twisted leg; a Great Dane with a life-threatening condition; a bulldog is rescued from a puppy mill.