What if simply getting too hot could be fatal to your child? Twins Andrew and Brandon, 7, have Ectodermal Dysplasia. Isolated by their condition, they meet 11-year-old Josh, who also has ED. Can their encounter bring them the friendship they all crave?

Tiffany and Destiny, 21, have never met but both live with the rare disease Osteogenesis Imperfecta (brittle bones). They set out on a life changing journey to meet each other, overcome their isolation and embark on a trip they never thought possible.