Roxie and Veronica are two gorgeous young women - who also happen to be highly trained contract killers. While on an errand for their boss, an unpleasant surprise in the trunk of their car turns this lethal pair into hunted targets.

Veronica & Roxie soon find their lives at risk. Mother deploys her two best hunters in Julian (Clifton Collins Jr.) & Kyle (Nathan Keyes) to eliminate the girls & bring the boy, Tyler (Jakob Salvati) in. Meanwhile, FBI Agent Frank Barnes (David Arquette) continues his search for Tyler.

Veronica and Roxie fight their would-be-assassins as they become the reluctant protectors of Tyler - and uncover the secret as to why the young boy is in such high demand. In the meantime, Barry is double crossed by Mother and moves up his prison escape plans to settle the score.