Rebecca lost weight to be more active with her young son, but the plan backfired because she is now trapped in her excess skin. After his dad died, Sal lost a lot of weight, but with all the excess skin, he fears he will never become a dad.

Autumn's excess skin from her major weight loss holds her back from quality time with her son. Cody always pretended to be happy when he was 500 lbs, but after losing the weight, he is covered in skin and is sick of pretending.

Ronnie and Michael Robinette are thriving to live the life they've work so hard for, but their extra skin is in their way; and at 64, Renee's excess skin inhibits her from enjoying her relationship and expressing her true self in public.